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By J. V. Chamary and Laurence D. Hurst. Key conceptS. Scientists long assumed that any DNA mutation that does not change the final protein encoded by a gene is effectively “silent.”
30 mar 2011 · There are various ways in which apparently 'silent' DNA mutations — those that don't result in a change in the encoded protein — have untoward consequences. A striking example has emerged in a...
6 sty 2021 · Objective This study describes the occurrence of a silent mutation in the RNA binding domain of nucleocapsid phosphoprotein (N protein) coding gene from SARS-CoV-2 that may consequence to a...
1 lut 2006 · Although the assumption of the neutral theory of molecular evolution — that some classes of mutation have too small an effect on fitness to be affected by natural selection — seems intuitively...
Understanding mechanisms by which synonymous mutations contribute to complex diseases such as cancer, neurodegeneration and genetic disorders, including the limitations of codon-optimized biologics, provides insight concerning interpretation of silent variants and future molecular therapies.
10 maj 2023 · We performed a comprehensive in silico analysis of silent mutations using somatic mutation data on 33 cancer types derived from the Cancer Genome Atlas (TCGA). We examined the changes in...
Types of mutations. Deletions a part of the DNA is missing anywhere from 1 base pair to parts of chromosomes. Insertions of new DNA again ranging from 1 to many base pairs. Point mutations; a change in the nucleotide. Two types. Transitions Purine to other purine or pyrimidine to other pyrimidine.
