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12 sie 2021 · In this study, we explore silent and non-silent mutations, aiming to quantify the predictive ability of various types of silent mutations to perform cancer diagnosis and to estimate...
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30 mar 2011 · There are various ways in which apparently 'silent' DNA mutations — those that don't result in a change in the encoded protein — have untoward consequences. A striking example has emerged in a...
10 maj 2023 · We performed a comprehensive in silico analysis of silent mutations using somatic mutation data on 33 cancer types derived from the Cancer Genome Atlas (TCGA). We examined the changes in...
2 maj 2016 · Until recently, most biologists believed that so-called silent mutations, created by ‘synonymous’ DNA changes—those that do not affect the protein-coding sequence—had very weak effects on the evolution of organisms.
23 cze 2023 · Synonymous variants, traditionally regarded as silent mutations due to their lack of impact on protein sequence, structure and function, have been the subject of increasing scrutiny. This commentary explores the emerging evidence challenging the notion of synonymous variants as functionally inert.
13 gru 2022 · A major presumption of the neutral theory of evolution proposed by Kimura in the late 1960s is that synonymous mutations (mutations that do not alter the primary sequence of a protein due to the redundancy of the genetic code) are supposed to be selectively neutral or nearly neutral (Kimura 1968 ).
By J. V. Chamary and Laurence D. Hurst. Key conceptS. Scientists long assumed that any DNA mutation that does not change the final protein encoded by a gene is effectively “silent.”
