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2 maj 2016 · Until recently, most biologists believed that so-called silent mutations, created by ‘synonymous’ DNA changes—those that do not affect the protein-coding sequence—had very weak effects on the evolution of organisms.
20 cze 2018 · A silent mutation is a change in the sequence of nucleotide bases which constitutes DNA, without a subsequent change in the amino acid or the function of the overall protein. Sometimes a single amino acid will change, but if it has the same properties as the amino acid it replaced, little to no change will happen.
By J. V. Chamary and Laurence D. Hurst. Key conceptS. Scientists long assumed that any DNA mutation that does not change the final protein encoded by a gene is effectively “silent.”
3 sie 2023 · An example of silent mutation is observed in the case where a thymine nucleotide is replaced by cytosine in a TTC codon, resulting in the formation of a TTT codon. The mRNA of the codons are AAG and AAA, respectively.
30 mar 2011 · In a paper in Nature Genetics, Brest and colleagues 2 provide evidence of an example of disruption in which a silent mutation affects the regulation, through microRNA, of the process of...
31 sie 2011 · Synonymous mutations — sometimes called 'silent' mutations — are now widely acknowledged to be able to cause changes in protein expression, conformation and function.
Silent mutations (also referred to as synonymous mutations) can also be described as single-nucleotide polymorphisms (SNPs) that result in no change to the amino acid sequence because of codon redundancy or degeneracy in the genetic code.
