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  1. 31 lip 2023 · The highest mortality burden from sickle cell disease was concentrated in sub-Saharan Africa (figure 3C, D), where our cause-specific analysis indicated 29 400 (95% UI 20 300–40 000) people died of sickle cell disease in 2021, an increase of 30·1% (–2·3 to 77·6) since 2000.

  2. 15 cze 2023 · Our findings show a strikingly high contribution of sickle cell disease to all-cause mortality that is not apparent when each death is assigned to only a single cause. Sickle cell disease mortality burden is highest in children, especially in countries with the greatest under-5 mortality rates.

  3. 15 cze 2023 · Total SCD mortality ranks 12th in all leading causes of death in children younger than 5 years globally, 28-places higher than cause-specific SCD mortality, demonstrating the enormous and under-appreciated burden of the disease. Read the full paper for more details.

  4. Global, regional, and national prevalence and mortality burden of sickle cell disease, 2000–2021: a systematic analysis from the Global Burden of Disease Study 2021

  5. Completed as part of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021, this study delivers a comprehensive global assessment of prevalence of sickle cell disease and mortality burden by age and sex for 204 countries and territories from 2000 to 2021.

  6. Sickle cell disease mortality burden is highest in children, especially in countries with the greatest under-5 mortality rates. Without comprehensive strategies to address morbidity and mortality associated with sickle cell disease, attainment of SDG 3.1, 3.2, and 3.4 is uncertain.

  7. 15 cze 2023 · A new analysis provides a more complete picture of sickle cell disease mortality burden by combining disease prevalence data in different age groups and trends in overall survival when factoring in resulting secondary conditions.

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