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Miller et al demonstrated that aging is a risk factor for the development of SIADH-like hyponatremia. This syndrome, which was latterly called chronic idiopathic SIADH, usually develops in a subset of older patients, who do not have an apparent underlying etiology.
19 kwi 2021 · Jun et al. demonstrate that attention to HIMs and medical optimisation must be a key component of any treatment strategy for correction of hyponatraemia in older people. They show how prescription of multiple HIMs results in additive risk, especially in combination with thiazide diuretics.
6 mar 2023 · SIADH treatment involves correction and maintenance of corrected sodium levels and correction of underlying abnormalities such as hypothyroidism or pulmonary or CNS infection. The goal of sodium correction is more than 130 mEq/L.
Both evaluation of neurological symptoms and classification by volaemia are essential for a correct diagnosis and treatment of the hyponatraemic elderly patient. The syndrome of inappropriate anti-diuretic hormone secretion (SIADH) is the most common cause of hyponatraemia in older people.
28 mar 2023 · We review the epidemiology, pathophysiology, and differential diagnosis of SIAD, and summarize recent evidence for therapeutic options beyond FR, with a focus on tolvaptan, urea, and sodium-glucose cotransporter 2 inhibitors.
13 lis 2015 · Current treatment of hyponatremia in syndrome of inappropriate antidiuretic hormone secretion often uses therapies with limited efficacy; the most commonly chosen monotherapy treatments, fluid restriction and isotonic saline, failed to increase the serum [Na +] by ≥5 mEq/L in 55% and 64% of monotherapy treatment episodes, respectively.
1 mar 2016 · In this review, we will cover the epidemiology and clinical effects of hyponatraemia due to SIADH, and discuss the treatment strategies available for the management of the syndrome. Hyponatraemia is the commonest electrolyte abnormality in clinical practice, occurring in 15–30% of hospital patients [4].
