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Telomere shortening is a recognized cause of aging, and several human aging-related diseases are precipitated by accelerated telomere dysfunction. The common laboratory mouse Mus musculus has...
23 paź 2023 · Smoom and colleagues developed a mouse strain with human-size telomeres. This mouse, termed Telomouse, is therefore an invaluable tool for studying human aging and cancer.
3 mar 2020 · Here, we show that telomerase deficient mice with short telomeres (G2-Terc−/−) have an hyper-activated mTOR pathway with increased levels of phosphorylated ribosomal S6 protein in liver ...
As a molecular biologist, you need to collect cheek swabs from edible dormice and related rodents and isolate DNA from the cheek cells. Then you’ll analyze the ends of the DNA, which are segments called telomeres. Telomeres don’t contain genes and thus don’t code for proteins.
15 maj 2012 · Telomeres have been linked with aging and disease and, in the case of mice, genetic manipulations that shorten or lengthen telomeres result, respectively, in decreased or increased longevity. Therapies that impact on telomere length are therefore expected to have an impact on health span.
24 maj 2018 · Short telomere syndromes (STSs) are accelerated aging syndromes often caused by inheritable gene mutations resulting in decreased telomere lengths. Consequently, organ systems with increased cell turnover, such as the skin, bone marrow, lungs, and gastrointestinal tract, are commonly affected.
Further inquiry at JAX, in its efforts to fully characterize the mice it uses in its own research and distributes to the global biomedical community, has revealed that telomere length varies between mouse species and subspecies.
