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Telomere shortening is a recognized cause of aging, and several human aging-related diseases are precipitated by accelerated telomere dysfunction. The common laboratory mouse Mus musculus has...
28 lis 2023 · Telomere shortening is a recognized cause of aging, and several human aging-related diseases are precipitated by accelerated telomere dysfunction. The common laboratory mouse Mus musculus...
24 maj 2018 · Short telomere syndromes (STSs) are accelerated aging syndromes often caused by inheritable gene mutations resulting in decreased telomere lengths. Consequently, organ systems with increased cell turnover, such as the skin, bone marrow, lungs, and gastrointestinal tract, are commonly affected.
3 mar 2020 · Here, we show that telomerase deficient mice with short telomeres (G2-Terc −/−) have an hyper-activated mTOR pathway with increased levels of phosphorylated ribosomal S6 protein in liver ...
Here, we show that a small-molecule activator of telomerase (TA-65) purified from the root of Astragalus membranaceus is capable of increasing average telomere length and decreasing the percentage of critically short telomeres and of DNA damage in haploinsufficient mouse embryonic fibroblasts (MEFs) ….
1 wrz 2001 · We show here that re‐introduction of one copy of the Terc gene in these mice via Terc +/− × Terc −/− crosses is sufficient to elongate critically short telomeres, rescue chromosomal instability and prevent severe proliferative defects in these mice.
2 mar 2020 · Mice, rats, or hamsters are immunized by giving biweekly injections of a purified antigen, cultured cells, or cDNA. For mice, if a pure, soluble protein antigen is being used and is abundant, a dose of 50-100 µg in adjuvant at each immunization is a sensible general recommendation; for rats and hams ….
