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Finally, TA-65 dietary supplementa-tion in female mice leads to an improvement of certain health-span indicators including glucose tolerance, osteo-porosis and skin fitness, without significantly increasing global cancer incidence. Key words: telomerase activation; TA-65; telomere length; aging; mouse.
In addition, we demonstrate that TA-65 is capable of increasing mouse telomerase reverse transcriptase levels in some mouse tissues and elongating critically short telomeres when supplemented as part of a standard diet in mice. Finally, TA-65 dietary supplementation in female mice leads to an improvement of certain health-span indicators ...
1 lis 2023 · Compared with mice with long telomere reserve, telomerase knockout mice showed reduced neurogenesis in the dentate gyrus, loss of neurons in the hippocampus and frontal cortex, and related to short-term memory deficits.
14 lut 2022 · Mouse studies indicate that telomere dysfunction can recapitulate IPF features. Mice with short telomeres induced by knockout of telomerase components show TAFs, inflammation and fibrosis...
22 mar 2011 · In addition, we demonstrate that TA-65 is capable of increasing mouse telomerase reverse transcriptase levels in some mouse tissues and elongating critically short telomeres when supplemented as part of a standard diet in mice.
15 maj 2012 · Telomeres have been linked with aging and disease and, in the case of mice, genetic manipulations that shorten or lengthen telomeres result, respectively, in decreased or increased longevity. Therapies that impact on telomere length are therefore expected to have an impact on health span. RESULTS:
17 paź 2019 · In agreement with longer telomeres, hyper-long telomere mice also showed a significantly lower accumulation of short telomeres at old age compared with the age-matched control mice (Fig....
