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17 paź 2019 · Short telomeres trigger age-related pathologies and shorter lifespans in mice and humans. In the past, we generated mouse embryonic (ES) cells with longer telomeres than normal (hyper-long...
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Chętnie wyświetlilibyśmy opis, ale witryna, którą oglądasz,...
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1 lis 2023 · Study in mice with dual deficiency of advanced Terc and apolipoprotein E (Terc/apoE-KO) have shown that telomere shortening may prevent AS [67]. Telomere depletion significantly inhibited the proliferative capacity of Terc/apoE-KO lymphocytes and macrophages activated by several mitogens.
24 maj 2018 · Short telomere syndromes (STSs) are accelerated aging syndromes often caused by inheritable gene mutations resulting in decreased telomere lengths. Consequently, organ systems with increased cell turnover, such as the skin, bone marrow, lungs, and gastrointestinal tract, are commonly affected.
Short telomeres in telomice. Smoom. R. et al. Nat Commun. 14, 6708 (2023) Telomeres maintain genome stability by protecting chromosome ends from DNA damage. Telomere shortening is a...
28 lis 2023 · Telomere shortening is a recognized cause of aging, and several human aging-related diseases are precipitated by accelerated telomere dysfunction. The common laboratory mouse Mus musculus has...
15 maj 2012 · Together, these results indicate that forced TERT expression in adult mice by using a gene therapy approach results in rescue of short telomeres in several tissues and prevention of telomere shortening in peripheral blood leukocytes from the same mice.
1 wrz 2001 · Reconstitution of telomerase activity is proposed as a potential gene therapy to prevent, or rescue, age‐related diseases produced by critical telomere shortening. However, it is not known whether or not short telomeres are irreversibly damaged.
