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17 paź 2019 · Short telomeres trigger age-related pathologies and shorter lifespans in mice and humans. In the past, we generated mouse embryonic (ES) cells with longer telomeres than normal (hyper-long...
28 lis 2023 · Telomere shortening is a recognized cause of aging, and several human aging-related diseases are precipitated by accelerated telomere dysfunction.
Abstract. A major goal in aging research is to improve health during aging. In the case of mice, genetic manipulations that shorten or lengthen telomeres result, respectively, in decreased or increased longevity. Based on this, we have tested the effects of a telomerase gene therapy in adult (1 year of age) and old (2 years of age) mice.
24 maj 2018 · Key clinical cues to suspect short telomeres in a patient are a personal or family history of premature graying of hair (at age <30 years), unexplained cytopenias, idiopathic pulmonary fibrosis, and cryptogenic cirrhosis.
14 lut 2022 · Mice with short telomeres display impaired insulin secretion and glucose intolerance associated with an accumulation of senescence markers, which suggests a causal role for telomere...
1 lis 2023 · Compared with mice with long telomere reserve, telomerase knockout mice showed reduced neurogenesis in the dentate gyrus, loss of neurons in the hippocampus and frontal cortex, and related to short-term memory deficits.
26 paź 2021 · Recent studies have demonstrated that patients with DC and murine models with critically short telomeres exhibit lower NAD levels, and an imbalance in the NAD metabolome, including elevated CD38 NADase and reduced poly (ADP-ribose) polymerase and SIRT1 activities.
