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In addition, we demonstrate that TA-65 is capable of increasing mouse telomerase reverse transcriptase levels in some mouse tissues and elongating critically short telomeres when supplemented as part of a standard diet in mice. Finally, TA-65 dietary supplementation in female mice leads to an improvement of certain health-span indicators ...
merase pathway. In addition, we demonstrate that TA-65 is capable of increasing mouse telomerase reverse trans-criptase levels in some mouse tissues and elongating criti-cally short telomeres when supplemented as part of a standard diet in mice. Finally, TA-65 dietary supplementa-tion in female mice leads to an improvement of certain
22 mar 2011 · In addition, we demonstrate that TA-65 is capable of increasing mouse telomerase reverse transcriptase levels in some mouse tissues and elongating critically short telomeres when supplemented as part of a standard diet in mice.
1 lis 2023 · Compared with mice with long telomere reserve, telomerase knockout mice showed reduced neurogenesis in the dentate gyrus, loss of neurons in the hippocampus and frontal cortex, and related to short-term memory deficits.
Pre-clinical data showed that TA-65, an oral telomerase activator, reduced immune ageing and inflammation after MI. We conducted a double blinded randomised controlled pilot trial evaluating the use of TA-65 to reduce immune cell ageing in patients following MI.
24 maj 2018 · Key clinical cues to suspect short telomeres in a patient are a personal or family history of premature graying of hair (at age <30 years), unexplained cytopenias, idiopathic pulmonary fibrosis, and cryptogenic cirrhosis.
3 mar 2020 · To address whether rapamycin treatment could ameliorate premature aging pathologies and decreased longevity in mice with short telomeres, 3-month-old wild type and second-generation...
