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8 kwi 2022 · The primary positive, negative, and cognitive symptoms of schizophrenia have been associated with many neurotransmitters, but the subcortical dopamine dysfunction remains to be the key factor in psychotic symptoms. Presynaptic dopamine dysfunction appears to mediate psychosis in schizophrenia.
- Dopamine and glutamate in schizophrenia: biology, symptoms and ...
Glutamate and dopamine systems play distinct roles in terms...
- The Role of Dopamine in Schizophrenia from a Neurobiological and ...
The revised dopamine hypothesis states that dopamine...
- Dopamine and glutamate in schizophrenia: biology, symptoms and ...
10 sty 2020 · Glutamate and dopamine systems play distinct roles in terms of neuronal signalling, yet both have been proposed to contribute significantly to the pathophysiology of schizophrenia. In this paper we assess research that has implicated both systems in the aetiology of this disorder.
19 maj 2014 · The revised dopamine hypothesis states that dopamine abnormalities in the mesolimbic and prefrontal brain regions exist in schizophrenia. However, recent research has indicated that glutamate, GABA, acetylcholine, and serotonin alterations are also involved in the pathology of schizophrenia.
18 gru 2023 · Abstract. Schizophrenia is a leading cause of global disability. Current pharmacotherapy for the disease predominantly uses one mechanism — dopamine D2 receptor blockade — but often shows...
31 sty 2018 · Understanding the neurobiology of schizophrenia presents substantial challenges but a key feature continues to be the involvement of subcortical dopaminergic dysfunction in those with psychotic...
23 sty 2023 · Dopamine occupies a central role in the pathophysiology of schizophrenia [144,145,146]. In preclinical models, increased dopamine signalling is associated with schizophrenia-like behaviours [...
7 wrz 2022 · It has been hypothesized since the 1960s that the etiology of schizophrenia is linked to dopamine. In the intervening 60 years, sophisticated brain imaging techniques, genetic/epigenetic advances, and new experimental animal models of schizophrenia have transformed schizophrenia research.
