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29 lis 2022 · We offer an angle on when and how to treat, and provide an overall roadmap for managing sarcoidosis. This review draws together recent publications, consensus statements on sarcoidosis and our 25-year collective experience in managing this disease.
As sarcoidosis may be self-limiting and remit spontaneously, a first challenge in its management is to decide whether pharmacological treatment can be postponed and possibly avoided without any significant impact on quality of life, organ damage or prognosis.
Methotrexate is one of the most commonly used corticosteroid-sparing therapies for sarcoidosis, due to its effectiveness, low cost and, at the dosages used to treat sarcoidosis, relatively low risk of side effects compared to other cytotoxic agents. The drug can be given orally or sub-cutaneously.
11 lis 2020 · Sarcoidosis is a multi-systemic granulomatous disease. Affected individuals can show spontaneous healing, develop remission with drug treatment within 2 years, or become chronically ill. Our main goal was to identify features that are related to prognosis.
Treatment usually is indicated in symptomatic patients. First-line treatment is corticosteroids. Prognosis is excellent for limited disease but poor for more advanced disease. Sarcoidosis most commonly affects people aged 20 to 40 years but occasionally affects children and older adults.
18 lis 2020 · Treatment is directed at alleviating organ dysfunction, preventing irreversible scarring, and improving quality of life. Herein, we review the indications for treatment, pharmacotherapy, treatment duration, side effects, adjunct non-pharmacologic therapies, and outcomes for patients.
5 maj 2023 · The survival graphs reflect the care of cardiac sarcoidosis based on the following principles: requirement of diagnostic histology and pursuit of definite diagnosis, consistent use of corticosteroids with azathioprine and infliximab as the main additional immunomodulators, clinical follow-up with selective instead of routine repeats of positron ...
