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11 wrz 2022 · Female predominance, pulmonary, ocular, skin and systemic symptoms are common, while more classical presentations such as Lofgren’s syndrome are uncommon. Positivity rates of biopsies vary between studies; however, targeted biopsies of accessible sites with organ involvement are the most successful.
29 kwi 2024 · Sarcoidosis is a multisystem granulomatous disorder that affects individuals worldwide. The disease was historically thought to present mainly in young or middle-aged adults, but more recent data suggest that it may also occur in the sixth and seventh decade of life, especially in females.
Background: The diagnosis of sarcoidosis is not standardized but is based on three major criteria: a compatible clinical presentation, finding nonnecrotizing granulomatous inflammation in one or more tissue samples, and the exclusion of alternative causes of granulomatous disease.
30 sty 2019 · Sarcoidosis can begin with these signs and symptoms: Fatigue. Swollen lymph nodes. Weight loss. Pain and swelling in joints, such as the ankles. Lung symptoms. Sarcoidosis most often affects the lungs and may cause lung problems, such as: Persistent dry cough. Shortness of breath. Wheezing. Chest pain. Skin symptoms.
21 lip 2024 · Sarcoidosis is a multisystem inflammatory disease of unknown etiology that predominantly affects the lungs and intrathoracic lymph nodes and is manifested by the presence of noncaseating...
Most common clinical manifestations of sarcoidosis are non-specific generalized symptoms like fever, fatigue, myalgias, arthritis which is also seen in various autoimmune disease that need to be differentiated from sarcoidosis.
This huge variability led scientists to search for clinical patterns of phenotypic variables in order to help the diagnosis and avoid, when possible, invasive procedures. Sarcoidosis can affect individuals of all ages but most commonly affects men aged 30 to 50 years, and women aged 40 to 60 years . Phenotypic differences in sarcoidosis subsets ...
