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1 lip 2000 · The mechanisms of abnormal calcium metabolism in sarcoidosis need to be understood when treating hypercalcaemia, hypercalcuria and corticosteroid‐induced osteoporosis. Studies are required to determine if the currently available therapies for osteoporosis are safe and effective in sarcoidosis.
Broadly based on the inciting mechanism, hypercalcemia is classified into PTH-dependent and independent causes. The most common causes of hypercalcemia include PTH-dependent hyperparathyroidism and malignancy which causes a PTH-independent hypercalcemia through PTHrP.
13 lis 2019 · Still, the overproduction of calcitriol is considered to be the leading cause of sarcoidosis-associated hypercalcemia. This leads to the conclusion that there exists a phenomenon of “inadequate normal” 1,25(OH)2D3 concentration in patients with sarcoidosis.
The increased levels of vitamin D in sarcoidosis patients may result in hypercalcemia. Although hypercalcemia is listed as a common laboratory finding in patients with sarcoidosis, it is rare for hypercalcemia to precipitate critical illness.
Hypercalcemia—Encourage fluid intake of >2 l per day and minimize their exposure to sunlight, avoid vitamin D and fish oil supplementation. Moderate hypercalcemia—May consider addition of corticosteroids and/or ketoconazole or hydroxychloroquine. Severe hypercalcemia—act immediately: rehydrate.
3 lis 2020 · In sarcoidosis, hypercalcaemia is a feature in only 10-20% of all cases. However, the manifestation of hypercalcaemia may be the first presentation of sarcoidosis in patients who do not show the classical features of acute sarcoidosis. Case report - Case description.
The unregulated hypercalcemia and hypercalciuria in sarcoidosis result from granulomas lacking negative feedback mechanisms [2]. Diagnosing sarcoidosis becomes challenging when severe hypercalcemia is the presenting symptom.
