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The glycoconjugate strategy for new Salmonella vaccines is principally an antibody approach. The majority of Salmonella conjugate vaccines employ the familiar carrier proteins, tetanus toxoid (TT), diphtheria toxoid (DT) and the nontoxic recombinant form of diphtheria toxin (CRM 197), as well as the less-commonly used protein, rEPA.
- Advances in the development of Salmonella-based vaccine ... - PubMed
In this review we focus on (1) recent advances in live...
- Advances in the development of Salmonella-based vaccine ... - PubMed
In this review we focus on (1) recent advances in live attenuated Salmonella vaccine development, (2) improvements in expression of foreign antigens in carrier vaccines and (3) adaptation of attenuated strains as sources of purified antigens and vesicles that can be used for subunit and conjugate vaccines or together with attenuated vaccine ...
Salmonella Vaccines. Though primarily enteric pathogens, Salmonellae are responsible for a considerable yet under-appreciated global burden of invasive disease. In South and South-East Asia, this manifests as enteric fever caused by serovars Typhi and Paratyphi A.
Therefore, in an effort to prevent Salmonella-induced gastroenteritis, as well as invasive Salmonella infections, a vaccine that targets serogroup C Salmonella along with S. Typhimurium and S. Enteritidis is desirable.
Increasing antibiotic resistance in Salmonella is concerning, and empiric oral options are being rapidly eroded. Where new effective antimicrobials are lacking, developments in vaccines offer hope for reducing the burden of Salmonella infections globally.
1 lis 2002 · The use of Salmonella vaccines as candidate typhoid fever vaccines and as carriers of heterologous antigens will be reviewed. In addition, problems associated with their development, and solutions to these problems, which have been devised, are discussed.
1 sty 2018 · Recombinant attenuated Salmonella vaccines (RASVs) have been significantly improved to exhibit the same or better attributes than wild-type parental strains to colonize internal lymphoid tissues and persist there to serve as factories to continuously synthesize and deliver rAgs.
