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The aim of the trial is to determine the safety of the iNTS- GMMA vaccine and study the immune response to vacci-nation. Primary, secondary and exploratory objectives are detailed in table 1.
14 lis 2023 · METHOD AND ANALYSIS: The Salmonella Vaccine Study in Oxford is a randomised placebo-controlled participant-observer blind phase I study of the iNTS-GMMA vaccine.
14 lis 2023 · Method and analysis: The Salmonella Vaccine Study in Oxford is a randomised placebo-controlled participant-observer blind phase I study of the iNTS-GMMA vaccine.
The glycoconjugate strategy for new Salmonella vaccines is principally an antibody approach. The majority of Salmonella conjugate vaccines employ the familiar carrier proteins, tetanus toxoid (TT), diphtheria toxoid (DT) and the nontoxic recombinant form of diphtheria toxin (CRM 197), as well as the less-commonly used protein, rEPA.
30 wrz 2024 · Effective vaccines against Salmonella-related diseases must stimulate both humoral immunity to combat extracellular bacteria and cellular immunity to eliminate intracellular pathogens. This multifaceted strategy is vital for effectively addressing Salmonella infections.
In this review we focus on (1) recent advances in live attenuated Salmonella vaccine development, (2) improvements in expression of foreign antigens in carrier vaccines and (3) adaptation of attenuated strains as sources of purified antigens and vesicles that can be used for subunit and conjugate vaccines or together with attenuated vaccine ...
6 wrz 2016 · INTRODUCTION. Animal models are indispensable tools for assessing candidate vaccines, with preclinical animal safety, immunogenicity, and efficacy data being prerequisite for regulatory agencies such as the U.S. Food and Drug Administration (FDA) prior to undertaking early-stage clinical trials. However, not all animal models are created equal.
