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The aim of the trial is to determine the safety of the iNTS- GMMA vaccine and study the immune response to vacci-nation. Primary, secondary and exploratory objectives are detailed in table 1.
In this review we focus on (1) recent advances in live attenuated Salmonella vaccine development, (2) improvements in expression of foreign antigens in carrier vaccines and (3) adaptation of attenuated strains as sources of purified antigens and vesicles that can be used for subunit and conjugate vaccines or together with attenuated vaccine ...
14 lis 2023 · Method and analysis: The Salmonella Vaccine Study in Oxford is a randomised placebo-controlled participant-observer blind phase I study of the iNTS-GMMA vaccine.
1 lip 2021 · In this study, reverse vaccinology, an in-silico approach was established to screen appropriate immunogen targets by calculating the immunogenicity score of 583 non-redundant outer membrane and secreted proteins of Salmonella. Herein among 100 proteins identified with top-ranked scores, 15 representative antigens were selected randomly.
A study developed a rapid and sensitive method for the detection of Salmonella in foodstuffs, with a LOD as low as 13 CFU/mL in pure culture. This method combines SRCA with a light-sensitive colourimetric assay (SRCA-C).
With other new vaccines under investigation, including live-attenuated, protein-based and GMMA vaccines, now is an exciting time for the Salmonella vaccine field. Keywords: vaccines, Salmonella, nontyphoidal, typhoid, enteric, global health, glycoconjugate, GMMA. Protection Against more than Diarrhea
1 sty 2022 · In this study, the possibility of an oral bacteria-based vaccine that can be safely used as a platform for large-scale, long-term immunization was evaluated. A well-known Salmonella strain that was previously considered as a vaccine delivery candidate was used.
