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14 lis 2023 · Salmonella Vaccine Study in Oxford is a first-in-human study of a novel vaccine against invasive non-typhoidal Salmonellosis (iNTS), a neglected disease largely affecting low- and middle-income countries.
14 lis 2023 · Method and analysis: The Salmonella Vaccine Study in Oxford is a randomised placebo-controlled participant-observer blind phase I study of the iNTS-GMMA vaccine.
The glycoconjugate strategy for new Salmonella vaccines is principally an antibody approach. The majority of Salmonella conjugate vaccines employ the familiar carrier proteins, tetanus toxoid (TT), diphtheria toxoid (DT) and the nontoxic recombinant form of diphtheria toxin (CRM 197), as well as the less-commonly used protein, rEPA.
14 cze 2017 · This review compiles the current knowledge acquired from past and present studies that have helped to define key parameters instrumental in the design of an efficient anti-Salmonella vaccine. Mechanisms of Salmonella -host interaction resulting in bacterial uptake, as well as the innate and adaptive anti- Salmonella protective immunity, are ...
30 wrz 2024 · Effective vaccines against Salmonella-related diseases must stimulate both humoral immunity to combat extracellular bacteria and cellular immunity to eliminate intracellular pathogens. This multifaceted strategy is vital for effectively addressing Salmonella infections.
In this review we focus on (1) recent advances in live attenuated Salmonella vaccine development, (2) improvements in expression of foreign antigens in carrier vaccines and (3) adaptation of attenuated strains as sources of purified antigens and vesicles that can be used for subunit and conjugate vaccines or together with attenuated vaccine ...
7 wrz 2020 · Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
