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14 lis 2023 · Salmonella Vaccine Study in Oxford is a first-in-human study of a novel vaccine against invasive non-typhoidal Salmonellosis (iNTS), a neglected disease largely affecting low- and middle-income countries.
14 lis 2023 · Method and analysis: The Salmonella Vaccine Study in Oxford is a randomised placebo-controlled participant-observer blind phase I study of the iNTS-GMMA vaccine.
22 paź 2024 · The study provided insights for public health, emphasising the importance of strengthening resistance monitoring, optimising vaccination strategies, formulating localised interventions, rationally allocating public health resources, improving environmental hygiene, promoting interdisciplinary collaboration, and raising public awareness and ...
The well-recognized clinical association between HIV infection and iNTS disease, particularly among individuals with CD4 counts below 200 cells/µl, 42 also appears to provide clear support for the importance of cell mediated immunity in defense against Salmonella.
In this review we focus on (1) recent advances in live attenuated Salmonella vaccine development, (2) improvements in expression of foreign antigens in carrier vaccines and (3) adaptation of attenuated strains as sources of purified antigens and vesicles that can be used for subunit and conjugate vaccines or together with attenuated vaccine ...
Salmonella Vaccines. Though primarily enteric pathogens, Salmonellae are responsible for a considerable yet under-appreciated global burden of invasive disease. In South and South-East Asia, this manifests as enteric fever caused by serovars Typhi and Paratyphi A.
Although there has been very little work on development of vaccines that can protect humans against Salmonella serogroup C infections, there are a variety of vaccines licensed for use in animals. Lessons learned from these vaccines can help to guide development of human vaccines.
