Search results
With other new vaccines under investigation, including live-attenuated, protein-based and GMMA vaccines, now is an exciting time for the Salmonella vaccine field. Keywords: vaccines, Salmonella, nontyphoidal, typhoid, enteric, global health, glycoconjugate, GMMA. Protection Against more than Diarrhea
Salmonella infections are caused by bacteria commonly found in a variety of animals, especially poultry, pigs, cattle and reptiles. Humans are usually infected by eating undercooked or contaminated food.
There are two vaccines for Salmonella approved by the Food and Drug Administration (FDA): the live attenuated Ty21a oral vaccine and intra-muscular Vi polysaccharide capsular vaccine, whereas several other vaccines such as the GMMA-based vaccine, glycoconjugate vaccine, O-antigen glycoconjugate vaccines, and new attenuated vaccines are still in ...
One subtype of iNTS, Salmonella enterica var Typhimurium, ST313, is highly prevalent in sub-Saharan Africa and is associated with multi-drug resistance, making vaccine against NTS an important public health priority. Vaccine Pipeline.
Salmonella Vaccines. Though primarily enteric pathogens, Salmonellae are responsible for a considerable yet under-appreciated global burden of invasive disease. In South and South-East Asia, this manifests as enteric fever caused by serovars Typhi and Paratyphi A. In sub-Saharan Africa, a similar disease burden results …
Although there has been very little work on development of vaccines that can protect humans against Salmonella serogroup C infections, there are a variety of vaccines licensed for use in animals. Lessons learned from these vaccines can help to guide development of human vaccines.
A Salmonella Bovismorbificans (Group C2) live attenuated vaccine has also been developed with the aim of reducing salmonellosis in sheep. This live attenuated Δ aroA vaccine was able to protect mice against a lethal challenge with wild-type Salmonella Bovismorbificans [97].
