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10 lis 2023 · Recent studies indicate that suppression of mitogenic signaling or CDK4/6 activity in S phase is sufficient to reset the cell cycle to a G1 state prior to progression through mitosis and is associated with reduced cyclin A expression.
10 wrz 2021 · During interphase, cell cycle progression is controlled before and after S phase. Commitment to enter a new cell cycle (that is, S phase entry) is made during a decision window preceding S phase.
The G1/S transition of the cell cycle is a critical control point for cell proliferation and a target of new cancer therapies. Rubin et al. describe the existing molecular models for G1/S regulation by the Cdk-Rb-E2F and other pathways, and they review recent studies that challenge those paradigms.
1 kwi 2021 · The cells become insensitive to growth inhibitory signals, and evade cell death. The cell cycle has four stages: mitosis, gap-1, synthesis phase (S-phase) and gap-2. DNA synthesis occurs in S-phase, chromosomes then align, separate, and cell division takes place during mitosis.
4 lis 2021 · Valerie Wells. Cancer Gene Therapy 29, 897–900 (2022) Cite this article. 922 Accesses. 17 Altmetric. Metrics. Abstract. The cell cycle is strictly programmed with control mechanisms that...
27 sty 2017 · Inhibition of CHK1 or WEE1 in cancer cells prevents cell cycle arrest during S or G2 phase and enables cell proliferation despite accumulation of DNA damage.
22 lip 2021 · Aberrancy in cell cycle progression is one of the fundamental mechanisms underlying tumorigenesis, making regulators of the cell cycle machinery rational anticancer therapeutic targets.
