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Rubella virus contains three major structural polypeptides: two membrane glycoproteins, E1 and E2 and a single nonglycosylated RNA-associated capsid protein, C, within the virion. One of the envelope proteins, E1, is responsible for viral hemagglutination and neutralization.
26 kwi 2021 · This review focuses on the life cycle of RUBV with emphasis on recent findings on the structures of the virus particle and its component proteins and on the mechanisms of virus entry, fusion, assembly, and budding.
7 paź 2020 · Ruhugu virus and rustrela virus are the first close relatives of rubella virus, providing insights into the zoonotic origin of rubella virus and the epidemiology and evolution of all...
26 kwi 2021 · This review concentrates on recent work on RUBV, focusing on the virion, its structural components, and its entry, fusion, and assembly mechanisms. Important features of RUBV are compared with those of viruses from other families.
6 sty 2013 · The structure indicates that the rubella virus E1 glycoprotein evolved to become distant from that of the mosquito-borne viruses in the same family, creating its own niche as a strictly...
2 cze 2017 · Here we report a helical structure of rubella virions using cryo-electron tomography. Sub-tomogram averaging of the surface spikes established the relative positions of the viral glycoproteins, which differed from the earlier icosahedral models of the virus.
Rubella, first described in 1814 7, is an acute, highly contagious human infectious disease typically characterized by rash, low-grade fever, adenopathy, and conjunctivitis 1.Research from the 1940s to 1960s revealed that rubella (also called “German measles”) contracted during the first trimester of pregnancy was directly associated with severe congenital birth defects, miscarriage, and ...
