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Structure. Rubella virus is a spherical, 40- to 80-nm, positive-sense, single-stranded RNA virus with spike-like, hemagglutinin-containing surface projections. An electron-dense 30 to 35 nm core is surrounded by a lipoprotein envelope.
8 sie 2023 · Rubella virus encodes two non-structural proteins (p90 and p150) and three structural proteins; glycoprotein (E1 and E2) and the capsid protein (CP). The E1 protein is responsible for receptor-mediated endocytosis and induces the immune response through hemagglutination-neutralizing epitopes.
Rubella virus (RuV) is the pathogenic agent of the disease rubella, transmitted only between humans via the respiratory route, and is the main cause of congenital rubella syndrome when infection occurs during the first weeks of pregnancy.
26 kwi 2021 · This review focuses on the life cycle of RUBV with emphasis on recent findings on the structures of the virus particle and its component proteins and on the mechanisms of virus entry, fusion, assembly, and budding.
Rubella virus is a member of the Togaviridae family of enveloped, positive-sense, single-stranded RNA viruses. 74 Rubella typically infects young adults, who present with suboccipital lymphadenopathy and a maculopapular rash that begins on the face and spreads to the torso and extremities.
26 kwi 2021 · This review concentrates on recent work on RUBV, focusing on the virion, its structural components, and its entry, fusion, and assembly mechanisms. Important features of RUBV are compared with those of viruses from other families.
First isolated from cell culture in 1962, 1 rubella virus contains a single-stranded positive sense RNA genome. 2 Rubella virus belongs to the Togaviridae family and is the sole member of the Rubivirus genus. It is the causative agent of rubella disease or so-called “German measles.”
