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1 gru 2022 · OVERVIEW. Interest in the use of metformin, an insulin-lowering drug, in PCOS increased when it was appreciated that insulin resistance played an important role in the pathophysiology of the disorder. However, we no longer recommend the use of metformin as a first-line therapy for any indication in women with PCOS.
Several effects have been reported as related to metformin in PCOS patients including restoring ovulation, reducing weight, reducing circulating androgen levels, reducing the risk of miscarriage and reducing the risk of gestational diabetes mellitus (GDM).
4 sie 2022 · Metformin is prescribed to women with PCOS at a beginning dose of 500-850 mg per day, which can be raised to 2000 mg per day if tolerated. Metformin in higher doses can help people lose weight and improve their lipid profiles, especially if they are obese and have PCOS.
23 paź 2003 · Results Meta-analysis showed that metformin is effective in achieving ovulation in women with polycystic ovary syndrome, with odds ratios of 3.88 (95% confidence interval 2.25 to 6.69) for metformin compared with placebo and 4.41 (2.37 to 8.22) for metformin and clomifene compared with clomifene alone.
Significantly more women with PCOS by updated guidelines should be taking metformin than women with PCOS by previous guidelines. Using the old guidelines 12% of patients should be taking metformin which increased to 91% using the new guidelines (p<0.0001).
first-line therapy for the treatment of women who are anovulatory and infertile with PCOS, metformin alone was significantly less effective than clomiphene citrate alone. 17,21 Furthermore, metformin does not improve metabolic
11 kwi 2021 · Three CPGs recommended combining LSTs with pharmacological treatments such as metformin to optimize weight loss after 6 months (13, 19, 20), and 3 recommended bariatric surgery in obese women with PCOS if LST alone failed to achieve sufficient weight loss (14, 15, 20).
