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Several effects have been reported as related to metformin in PCOS patients including restoring ovulation, reducing weight, reducing circulating androgen levels, reducing the risk of miscarriage and reducing the risk of gestational diabetes mellitus (GDM).
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The cumulative incidence of diabetes was lower in the...
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The classification of diabetes mellitus and the tests used...
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11 sty 2024 · In clinical practice, metformin is a recommended first step for managing PCOS in overweight or obese patients, particularly when oral contraceptives are not suitable or insulin...
1 cze 2010 · Metformin produces normoglycemia by decreasing hepatic glucose production, the intestinal absorption of glucose, and improving insulin sensitivity, thus promoting glucose uptake and utilization...
11 kwi 2021 · Three CPGs recommended combining LSTs with pharmacological treatments such as metformin to optimize weight loss after 6 months (13,19,20), and 3 recommended bariatric surgery in obese women with PCOS if LST alone failed to achieve sufficient weight loss (14,15,20).
23 paź 2003 · Results Meta-analysis showed that metformin is effective in achieving ovulation in women with polycystic ovary syndrome, with odds ratios of 3.88 (95% confidence interval 2.25 to 6.69) for metformin compared with placebo and 4.41 (2.37 to 8.22) for metformin and clomifene compared with clomifene alone.
Among these guidelines are updated recommendations for the use of metformin in patients with PCOS. These recommendations advise that patients with PCOS and BMI≥25, impaired glucose tolerance, and/or adolescents age <18 should take metformin to prevent metabolic sequelae of PCOS (1).
31 sie 2023 · Many studies showed that metformin, when used to treat PCOS, significantly reduced serum androgen levels, improved insulin sensitivity, restored menstrual cyclicity, and was successful in triggering ovulation. As a result, metformin may be useful in treating PCOS-related infertility.
