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22 lip 2020 · Cu-dependent lysyl oxidase (LOX) plays a catalytic activity-related, primary role in the assembly of the extracellular matrix (ECM), a dynamic structural and regulatory framework which is essential for cell fate, differentiation and communication during development, tissue maintenance and repair.
1 lis 2020 · The lysyl oxidases (LOXs) are a family of secreted copper-dependent enzymes which initiate the covalent crosslinking of collagen and elastin fibers in the extracellular microenvironment, thereby facilitating extracellular matrix (ECM) remodeling and ECM homeostasis.
11 maj 2021 · In humans, its ortholog is encoded by ALOX15 and has been referred to as “15-LOX-1” or human reticulocyte type 12/15-LOX. Its activity favors the production of 15-HETE and leads to small amounts of 12-HETE in a ratio of 9:1 from arachidonic acid [20,21].
31 mar 2022 · Redox homeostasis is a prerequisite for human health, in which the physiological levels of nonradical reactive oxygen species (ROS) function as the primary second messengers to modulate physiological redox signaling by orchestrating multiple redox sensors.
3 lip 2019 · Arachidonate 15-lipoxygenase type B (ALOX15B), which is also expressed in human macrophages (Wuest et al., 2012), catalyzes the stereo-specific peroxidation of PUFAs to the same hydroperoxy derivatives as ALOX15 (Kutzner et al., 2017).
1 gru 2015 · In humans, this inherited disease is known as autosomal recessive congenital ichthyosis (ARCI) (MIM#s 190195, 242100, 242300). Biochemically, 12R-LOX reacts readily with linoleate rather than arachidonate to produce 9R-HPODE ( Fig. 1 B).
14 paź 2019 · Lysyl oxidases (LOX and LOX-likes (LOXLs) isoenzymes) belong to a family of copper-dependent enzymes classically involved in the covalent cross-linking of collagen and elastin, a pivotal process that ensures extracellular matrix (ECM) stability and provides the tensile and elastic characteristics of connective tissues.
