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7 lip 2018 · Although chronic respiratory failure can be supported rather effectively with NIV, acute episodes are much more difficult to manage. Generation of adequate cough is vital for mucus clearance during these acute episodes and is often significantly limited in patients with ALS.
28 kwi 2022 · Consequently, the most common cause of death for people with ALS is respiratory failure. To prevent this, some people in the end stages of the disease could permanently need ventilatory support. 2 Other patients may choose to undergo a tracheostomy to facilitate full-time respirator use. 2
Up to 95% of patients with ALS in the United States choose not to undergo tracheostomy; management of respiratory failure is therefore aimed at both prolonging survival as well as improving quality of life.
15 kwi 2015 · ALS leads to death in 15 to 20 months after diagnosis in 50 % of patients [2••], generally due to respiratory failure. An older age and bulbar involvement at onset are the main negative prognostic factors. Ten percent survives more than 10 years.
19 sty 2023 · A comprehensive, multidisciplinary approach to ALS respiratory care may minimize hospitalizations for acute respiratory failure, reduce need for emergent tracheostomy, improve patient-reported outcome measures, and facilitate developing clinical research initiatives.
23 maj 2023 · Abstract. Amyotrophic lateral sclerosis (ALS) is a neurodegenerative condition noteworthy for upper and lower motor neuron death. Involvement of respiratory motor neuron pools leads to progressive pathology.
Amyotrophic lateral sclerosis (ALS) is an incurable disease whereby patients most commonly die of respiratory complications. It is important for pulmonary physicians to be aware of this and understand management options, including noninvasive and invasive ventilation and assisted cough techniques.
