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7 lip 2018 · Although clinical presentations can vary, there is no cure for ALS, and the disease is universally terminal, with most patients dying of respiratory complications. Patients die, on average, within 3 to 5 years of diagnosis, unless they choose to undergo tracheostomy, in which case, they may live, on average, 2 additional years.
Although clinical presentations can vary, there is no cure for ALS, and the disease is universally terminal, with most patients dying of respiratory complications. Patients die, on average, within 3 to 5 years of diagnosis, unless they choose to undergo tracheostomy, in which case, they may live, on average, 2 additional years.
19 sty 2023 · A comprehensive, multidisciplinary approach to ALS respiratory care may minimize hospitalizations for acute respiratory failure, reduce need for emergent tracheostomy, improve patient-reported outcome measures, and facilitate developing clinical research initiatives.
15 kwi 2015 · ALS leads to death in 15 to 20 months after diagnosis in 50 % of patients [2••], generally due to respiratory failure. An older age and bulbar involvement at onset are the main negative prognostic factors. Ten percent survives more than 10 years.
The majority of ALS patients are either on MIE or should be at some point in the disease process. In general, their lungs are free from pathology and O2 (as loud as one expects from an O2 concentrator behind a patient's head) is not indicated and the same for nebulizer function.
23 maj 2023 · Respiratory upper and lower motor neuron degeneration in ALS leads to weakness and atrophy of the inspiratory and expiratory muscles, as well as muscles of the upper airway. Isolated or combined dysfunction of these motor neuron pools leads to hypoventilation, dystussia, and dysphagia in patients. Open in viewer.
ALS with respiratory onset has some common clinical features: male predominance, frequent camptocormia or dropped head, frequent widespread fasciculations, limb mobility fairly well preserved and significant weight loss in the early stages.
