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19 sty 2023 · A comprehensive, multidisciplinary approach to ALS respiratory care may minimize hospitalizations for acute respiratory failure, reduce need for emergent tracheostomy, improve patient-reported outcome measures, and facilitate developing clinical research initiatives.
Fifteen years have elapsed since noninvasive ventilation was shown to improve survival and quality of life for patients with amyotrophic lateral sclerosis (ALS). 1 Since that time, extraordinary technological advances in home-assisted ventilation and airway clearance devices have dramatically expanded opportunities to optimize respiratory care ...
7 paź 2021 · In our study, the risk of early death was nearly three times higher in FTD-ALS patients than in ALS patients alone, and the presence of executive dysfunction in non-demented ALS patients might affect the longevity of survival.
Up to 95% of patients with ALS in the United States choose not to undergo tracheostomy; management of respiratory failure is therefore aimed at both prolonging survival as well as improving quality of life.
Early recognition of respiratory decline and symptomatic intervention, including non-invasive ventilation can significantly enhance both quality of life and life expectancy in ALS. Patients with respiratory failure should be advised to consider an advance directive to avoid emergency mechanical ventilation.
The median survival time from onset to death ranges from 20 to 48 months, but 10–20% of ALS patients have a survival longer than 10 years. Older age and bulbar onset are consistently reported to have a worse outcome. There are conflicting data on gender, diagnostic delay and El Escorial criteria.
