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Abstract. Amyotrophic lateral sclerosis is a progressive neuromuscular disease characterized by both lower motor neuron and upper motor neuron dysfunction. Although clinical presentations can vary, there is no cure for ALS, and the disease is universally terminal, with most patients dying of respiratory complications.
23 mar 2018 · Objective: Amyotrophic lateral sclerosis (ALS) is a progressive neuromuscular disease that causes skeletal muscle weakness, including muscles involved with respiration. Death often results from respiratory failure within 3–5 years.
23 maj 2023 · Ultimately, respiratory complications account for a large portion of morbidity and mortality in ALS. This state-of-the-art review highlights applications of respiratory therapies for ALS, including lung volume recruitment, mechanical insufflation-exsufflation, non-invasive ventilation, and respiratory strength training.
19 sty 2023 · A comprehensive, multidisciplinary approach to ALS respiratory care may minimize hospitalizations for acute respiratory failure, reduce need for emergent tracheostomy, improve patient-reported outcome measures, and facilitate developing clinical research initiatives.
22 lut 2022 · Respiratory dysfunction is a common cause of morbidity and mortality in many neuromuscular disorders, but particularly important in motor neuron diseases (MND), such as amyotrophic lateral sclerosis (ALS) or spinal muscular atrophy (SMA).
1 lut 2019 · Respiratory system dysfunction is the terminal event for most patients with ALS. Despite variable presentations, a vast majority of patients eventually experience difficulty with speech, airway clearance, and aspiration as bulbar muscle coordination declines. 6 In ALS, the respiratory system is affected at several functional and anatomic levels.
