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CRRT effluent rate is multiplied by the dilution factor and then divided by patient weight to reflect actual CRRT dose in ml/kg/hr; this takes into account the dilution effect. Dilution Factor = Plasma Flow Rate (ml/hr) / [Plasma Flow Rate (ml/hr) + Pre-Filter Replacement Fluid Rate (ml/hr) + PBP Fluid Rate (ml/hr)*]
A combined equation may be either a mean value equation, ie the mean of estimations of GFR with either marker, or a composite equation containing both markers.
24 lip 2023 · Renal blood flow (RBF) and glomerular filtration are important aspects of sustaining proper organ functions. A delicate balance exists between renal blood flow and the glomerular filtration rate as changes in one may affect the other.
Symbols. = dose. = dosing interval CL = clearance Vd = volume of distribution ke = elimination rate constant ka = absorption rate constant. = fraction absorbed (bioavailability) K0 = infusion rate. = duration of infusion. = plasma concentration.
Renal Blood Flow •Actual volume of blood going thru kidney (20-25% of body total of 5 L) •Blood = Plasma + Hematocrit •Equation corrects for hematocrit •Normally 1 – 1.25 L/min
Blood flow is highest in the cortex, averaging 4 to. 5 mL/min per gram of tissue. The high cortical blood flow permits a high rate of filtration in the glomeruli. Blood flow (per gram of tissue) is about 0.7 to 1 mL/min in the outer medulla and 0.20 to 0.25 mL/min in the inner medulla.
and renal blood flow. The GFR is equal to the sum of the filtration rates of all the functioning nephrons and thus is an important index of kidney function and it is used clinically as a global marker of kidney function. A decreasing GFR is a sensitive and vitally important marker of worsening kidney function.
