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15 paź 2024 · In the group with MMVD, 4 dogs with MMVD B2 and 1 dog with MMVD C had increased RDW (range: 14.5% to 16.3%), with mild anemia (normocytic, normochromic) identified in only one of them. Notably, this animal had no additional comorbidities at the time of diagnosis.
Hematology (Complete Blood Count) Reference Ranges. Data on various species compiled and adapted in part from multiple sources, including Latimer KS, Duncan & Prasse’s Veterinary Laboratory Medicine: Clinical Pathology, 5th ed., Wiley-Blackwell, 2011; and Weiss DJ, Wardrop KJ, Schalm’s Veterinary Hematology, 6th ed., Wiley-Blackwell, 2010.
Studies such as Neiger et al. (2002) in normal dogs with regenerative anemia and not based on the parameter of regenerative RDW found the values of 15.6 ± 1.35 for normal dogs, 15.3 ± 3.93 for regenerative anemia and 16.2 ± 2, 78 for dogs with non-regenerative anemia.
Dogs with RDW in the second (RDW = 13.6–14.4%) and third tercile (RDW > 14.4%) had significantly lower survival time and higher risk of death (HR = 2.09 and 2.5, 95% CI = 1.25–3.50 and 1.47–4.23; p = 0.005 and p < 0.001, respectively) when compared to dogs with RDW in the first tercile (RDW < 13.6%).
Red Blood Cell Distribution Width (RDW): Relation with Veterinary Diseases. Several studies have shown that elevated RDW could be useful in the differential diagnosis of the nature of a benign or malignant breast tumor, being significantly higher in the group of breast can- cer patients (Figure 3).
The “normal” range should reflect the “reference” of 95% of the animals. Most automated hematology analyzers have pre-set reference ranges based on literature references or clinical studies. However, it is recommended that each clinic establishes its own reference ranges.
Significantly higher RDW values were found in dogs with primary immune-mediated hemolytic anemia (P < 0.0001), immune-mediated thrombocytopenia (P < 0.0004), hyperadrenocorticism (P < 0.0001), hypothyroidism (P = 0.0220), hepatic vascular anomaly (P < 0.0001), pneumonia (P < 0.0001), chronic kidney disease (P = 0.0005), multi-centric lymphoma ...
