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Toxicity. Pyrimethamine is very safe and well tolerated. Occasionally megaloblastic anaemia, neutropenia, or thrombocytopenia may develop in patients with pre-existing folate deficiency.
Side effects of pyrimethamine include blood dyscrasias, rash and, very rarely, seizures or shock. At high doses, pyrimethamine causes bone marrow suppression, which can be prevented by concurrent administration of folinic acid (leucovorin).
16 lis 2012 · Pyrimethamine (Pyr) is a folate antagonist with a variety of indications. We report on the inadvertent poisoning of patients with Pyr who underwent bone marrow (BM) biopsy. There were 17 patients (median age 54); the most common presentation was gastrointestinal bleeding and pancytopenia.
16 lis 2012 · Pyrimethamine (Pyr) is a folate antagonist with a variety of indications. We report on the inadvertent poisoning of patients with Pyr who underwent bone marrow (BM) biopsy. There were 17 patients (median age 54); the most common presentation was gastrointestinal bleeding and pancytopenia.
25 lut 2020 · If overdose is suspected: If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
Pyrimethamine inhibits the dihydrofolate reductase of plasmodia and thereby blocks the biosynthesis of purines and pyrimidines, which are essential for DNA synthesis and cell multiplication. This leads to failure of nuclear division at the time of schizont formation in erythrocytes and liver.
27 sty 2024 · Side Effects of pyrimethamine. Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur: Rare. Chest pain; dry cough; fever; rapid or trouble ...
