Search results
3 sie 2015 · Normal PT in dogs is less than 22 seconds, but this can vary from laboratory to laboratory. Values greater than 22 seconds indicate a potential bleeding disorder. The most common cause of a prolonged PT is poisoning with an anticoagulant rodenticide.
Prothrombin time (PT) measures the functional activity of the coagulation factors involved in the extrinsic and common pathways. These parameters are measured by the amount of time it takes for a fibrin clot to form after calcium and different activating factors are added to a blood sample.
Dogs with low concentrations of factor VII will have normal aPTT, with prolonged PT. Depending on the results of coagulation testing, further investigations may involve specific analysis to determine the activities of individual coagulation factors.
Hypofibrinogenemia, accompanied by severe bleeding, has been reported in Saint Bernards and Vizslas and in one mixed-breed dog; the ACT, APTT, PT, and thrombin time (TT) were prolonged. Dysfibrinogenemia has been reported in an inbred family of Borzois.
A bit less than half of dogs and cats that develop disseminated intravascular coagulation (DIC) experience abnormally long PT times. PT times tend to be longer in newborn cats and dogs. Sulfa-type antibiotics, such as trimethoprim/sulfa has been known to increase bleeding and extend PT time.
Together with a CBC and basic blood chemistry results, a coagulation profile of PT, PTT, TT, and vWF can help a veterinarian determine which pathway of the coagulation system is malfunctioning. From there, further testing may be required to finish the diagnosis.
The PT is a unitized coagulation test intended for in vitro use in performing a quantitative, one-stage prothrombin time. The PT test is performed using fresh canine, feline, or equine whole blood. This test is to be used with the Coag Dx* Analyzer and is also compatible with the SCA2000* Coagulation Analyzer.
