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Pseudomonas aeruginosa PAO1 is an aerobe, Gram-negative human pathogen that was isolated from infected wound. Gram-negative; aerobe; human pathogen; 16S sequence; Bacteria; genome sequence
31 sie 2000 · Here we report the complete sequence of P. aeruginosa strain PAO1. At 6.3 million base pairs, this is the largest bacterial genome sequenced, and the sequence provides insights into the...
22 cze 2021 · The wild-type parent of PAO1 was lost, and PAO1 carries a regulatory mutation introduced for positive genetic selection that affects antibiotic resistance, virulence, quorum sensing, and other traits.
10 paź 2019 · The sequence of PAO1 is 6.3 Mbp in size (5570 predicted open reading frames), which in the year 2000, made it one of the largest bacterial genomes sequenced. It is important to note that there is phenotypic and genomic variation between PAO1 strains stored in different laboratories throughout the world, which is a consideration for the ...
13 paź 2022 · Pseudomonas aeruginosa is a ubiquitous, motile, gram-negative bacterium that has been recently identified as a multi-drug resistant pathogen in critical need of novel therapeutics. Of the approximately 5,000 strains, PAO1 and PA14 are common laboratory reference strains, modeling moderately and hyper-virulent phenotypes, respectively.
6 sty 2020 · The genome sequence of P. aeruginosa PAO1161 strain, a derivative of the reference PAO1 strain, was compared with the reference PAO1 sequence. The data indicated a number of sequence variants, thus sequencing, providing insight into genotypes of laboratory strains, is highly recommended to help in the interpretation of phenotypes observed in ...
The sequence reads were mapped to the PAO1-UW reference sequence (NC_002516) using Illumina's ELAND aligner (efficient large-scale alignment of nucleotide databases). ELAND aligns a large number of short reads to reference sequences, allowing up to two mismatches in the first 32 bases of a read.
