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30 cze 2022 · The standard conversion factors are included to allow dose translation between animals to humans and humans to animals expressed either in mg/kg or mg/m2. The estimation of a safe starting...
Therefore, extrapolation of dose from animals to humans needs consideration of body surface area, pharmacokinetics, and physiological time to increase clinical trial safety. Human equivalent dose calculation based on body surface area*
dosing. The recommended dose in cats is 3 to 5 mg/kg PO Q 24 H.3,17 Amantadine is also available as an oral liquid, but it is usually not palatable to cats.3 Cautions. • Side Effects: Although no adverse drug event pro-file exists for cats, reported side effects in dogs include agitation, loose stools, and flatulence, especially early in therapy.
In case of comparative approach, different methods are utilized to determine initial dose, and the data are compared and optimize to get an initial dose. Allometric scaling is an empirical approach where the exchange of drug dose is based on normalization of dose to body surface area.
3 maj 2016 · The goal of treatment is to restore euthyroidism with the smallest possible single dose of 131 I, while at the same time avoiding development of hypothyroidism. 54 Controversy exists as to the best method of calculating the optimum 131 I dose for individual cats. 64,65 No dose selection method
As described above, confusion and concerns emanated from a recent study by Baur et al. (2), where a dose of 22.4 mg/kg (body weight) of resveratrol was used in a mouse study on aging and obesity-related disorders.
Dose Calculations and Examples. The dose by factor method applies an exponent for body surface area (0.67), which account for difference in metabolic rate, to convert doses between animals and humans. Thus, HED is determined by the equation: HED ( mg/kg ) = Animal NOAEL ( mg/kg ) × ( Weight [ kg ] /Weigth [ kg ] )(.
