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Therefore, extrapolation of dose from animals to humans needs consideration of body surface area, pharmacokinetics, and physiological time to increase clinical trial safety. Human equivalent dose calculation based on body surface area*
30 cze 2022 · The authors describe four approaches to selecting a safe starting dose for humans in clinical drug trials based on interspecies scaling of clearance.
The dose by factor method applies an exponent for body surface area (0.67), which account for difference in metabolic rate, to convert doses between animals and humans.
Understanding the concept of extrapolation of dose between species is important for pharmaceutical researchers when initiating new animal or human experiments. Interspecies allometric scaling for dose conversion from animal to human studies is one ...
The recommended daily dose of CR was approximately 12 g/60 kg body weight in humans, and the corresponding dose of CRex for mice, considering the yield of CR to CRex, was 200 mg/kg; when we ...
1 mar 2016 · The standard conversion factors are included to allow dose translation between animals to humans and humans to animals expressed either in mg/kg or mg/m2.
The estimation of a safe starting dose is important to ensure the safety and tolerability of humans during phase-I clinical trials. Keywords: Starting dose, Body surface area, Dose translation, Human equivalent dose, Animal equivalent dose, Interspecies dose conversion, Allometric scaling. DOI: 10.5530/ijper.56.3.108 Correspondence: Prof. Shery ...
