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Proteases are key factors in the health and viability of cells, involved in multiple processes, such as replication, transcription, cell proliferation, differentiation, extracellular matrix remodeling, and processing of hormones and biologically active peptides.
Provides a comprehensive investigation into the regulation of proteases and their pathological consequences in health and disease. Explores the specific inhibitors and molecular probes for proteases to improve therapy for various diseases.
First volume to comprehensively explore the role of proteases in various diseases; Provides information on the pathogenesis of cellular dysfunction, with strong emphasis on identifying proteases and their endogenous inhibitors as targets for drug development
major proteases responsible for intracellular protein degradation. • Evolutionary clans and families of proteases have been identified, and the classification of individual proteases is highly developed. • Proteases regulate fate, localization, and activity of many proteins. • Proteasesarekeyfactorsinthehealthandviabilityofcells,
1 lut 2019 · Proteases and protein degradation play crucial roles in living systems, and I briefly address future directions in this highly diverse and thriving research area. Keywords: astacins; meprins; metalloprotease; metalloproteinase; protein complex; protein degradation; protein domain; proteinase.
Thus, proteases regulate the fate, localization, and activity of many proteins, modulate protein-protein interactions, create new bioactive molecules, contribute to the processing of cellular information, and generate, transduce, and amplify molecular signals.
Approaching proteolysis as the most important, irreversible post-translational protein modification essentially requires an integrated effort of complementary research disciplines. In fact, proteolytic enzymes seem as diverse as the scientists working with these intriguing proteins.
