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30 lip 2021 · The basic objective of this paper is to refine the definition of the term Brain-on-a-Chip for future generations of in vitro platforms, to ensure that the concept continues to refer to systems that provide meaningful advantages over conventional in vitro approaches.
10 maj 2019 · A possible improvement lies in the use of in vitro models of brain disorders. In vitro models can target a specific mechanism and investigate possible treatment. Adversely, in vitro models usually do not exhibit all symptoms that are clinically associated with the disorder.
10 maj 2019 · Over the past century, robust methods were developed that enable the isolation, culture, and dynamic observation of mammalian neuronal networks in vitro. But even if neuronal culture cannot yet fully recapitulate the normal brain, the knowledge that has been acquired...
Here, we describe an efficient in vitro system to propagate a large number of highly purified murine memory monocytes through sustaining bone marrow–derived monocytes with macrophage colony-stimulating factor (M-CSF, 10 ng/mL)-containing medium, together with other polarization agents such as lipopolysaccharide (LPS) for a 5-day period.
26 lip 2023 · Memory is an essential cognitive function that permits individuals to acquire, retain, and recover data that defines a person’s identity (Zlotnik and Vansintjan, 2019). Memory is a multifaceted cognitive process that involves different stages: encoding, consolidation, recovery, and reconsolidation.
16 kwi 2024 · Innate monocytes can be trained or reprogrammed to adopt distinct memory states, such as low-grade inflammation and immune exhaustion, bearing fundamental relevance to the pathogenesis of both acute diseases such as sepsis as well as chronic diseases such as atherosclerosis.
14 paź 2009 · In the forty years since the Society for Neuroscience was founded, our understanding of the biology of memory has progressed dramatically. From a historical perspective, one can discern four distinct periods of growth in neurobiological research during that time.
