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4 cze 2020 · We outline key aspects that should be considered when developing, qualifying, and implementing complex in vitro models (CIVMs) during these phases, because criteria such as cell types (e.g.,...
21 sty 2022 · PDF | Complex in vitro models (CIVM) offer the potential to improve pharmaceutical clinical drug attrition due to safety and/or efficacy, but for this... | Find, read and cite all the...
25 paź 2023 · Here, we describe the three phases of effectively designing a preclinical research protocol: the research, preprocedural planning, and experimental phases. Furthermore, we provide researchers with...
drug candidates are performed in vitro, using a wide variety of time- and cost-effective techniques in order to define which compounds should progress to the next stage in the drug development process. Monolayer cultures are the easiest and most ‘controllable’ models for the evaluation of drug potency for most cytotoxic agents.
28 paź 2021 · In vitro models is a hybrid journal published by Springer (part of Springer Nature), and it is the first of the kind focusing on research that deals with the upcoming and impactful field of in vitro models.
In vitro and in vivo models play integral roles in preclinical drug research, evalu-ation, and precision medicine. In vitro models primarily involve research plat-forms based on cultured cells, typically in the form of two-dimensional (2D) cell models. However, notable disparities exist between 2D cultured cells and in vivo
validation methods used by in vitro diagnostic medical device manufacturers in their research and development (R&D), quality control, and quality assurance laboratories.
