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5 sty 2022 · Second, the nuclear dense fine-speckled (AC-2) and Topo I-like (AC-29) patterns are realigned closer to the nuclear homogeneous pattern (AC-1) to highlight their similarities in staining of both interphase nuclei and mitotic condensed chromatin.
These are defined patterns and have respective antibody targets, immunological associations, and clinical relevance. The nuclear dense fine speckled pattern (AC-2), on the other hand, should be distinguished from the nuclear speckled patterns AC-4 and AC-5 based on the positive staining of the metaphase plate.
The speckled pattern, one of several distinct patterns identified in ANA testing, is associated with antibodies targeting extractable nuclear antigens (ENAs), such as Sm, RNP, SS-A, and SS-B.
19 maj 2015 · 1) Prominent fine speckled AC-4 type nuclear staining in interphase cells. 2) Consistent strong fine speckled staining of condensed chromatin in mitotic cells. Depending on the serum dilution used, the mitotic chromatin staining may appear homogeneous.
21 lut 2024 · ANA patterns can be associated with different autoimmune conditions. These patterns can range from homogenous to speckled, and each carries its own significance in terms of potential autoimmune conditions. Below is a summary of the patterns discussed: Homogenous pattern: Also called nuclear homogenous.
1 sie 2020 · ICAP-oriented IB detected 515 antibody reactivities vs. 457 of traditional anti-ENA in the nuclear speckled pattern group, 108 vs. 28 in the nucleolar pattern group, and 43 vs. 34 in the cytoplasmic speckled pattern.
23 lis 2020 · The highest scores for clinical relevance were obtained for the centromere (AC-3) and homogeneous (AC-1) pattern, followed by the nuclear speckled (AC-2,4,5) and cytoplasmic reticular (AC-21) patterns.
