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19 sie 2022 · Abstract. The contemporary pharmaceutical industry is voicing growing concerns about the translatability and reproducibility of animal models. In addition, the usefulness of certain of the required regulatory safety tests in animals is being increasingly questioned.
The available data, however, suggest that the number of animals used in research and testing in the Western world peaked in the 1970s, and decreased until the late 1990s, or early 2000s, to about half the number of 30 years earlier, and stabilizing in recent years.
7 wrz 2011 · This Overview provides a brief summary of the ethical and scientific considerations regarding the use of animals in research and testing, and accompanies a Collection entitled Animals, Research, and Alternatives: Measuring Progress 50 Years Later, which aims to spur ethical and scientific advancement.
21 paź 2020 · Here we present a mini-review on the development of animal testing, as well as on alternative in vitro and in silico methods, that may at least partly replace animal experiments in the near future.
1 mar 2019 · Animal testing has been central to pre-clinical drug development for several decades, yet there remains no substantial, robust, published evidence that this has a scientific basis—i.e. that these tests are reliably predictive of human responses, both with respect to efficacy and toxicity/safety.
24 kwi 2019 · Animal testing is often a controversial and emotionally-charged subject. It’s a mental space that people almost never encounter in their day-to-day lives: that animals, which are sentient and can feel pain, are being instrumentalised at a scale of approximately 4 million animals per annum in the UK alone.
11 paź 2022 · In this article, I present four examples of animal tests that were introduced in the past to protect patients and consumers, and I discuss attempts to replace those animal tests with other...
