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Various analytical methods are currently available for measuring bilirubin and its metabolites in serum, urine and feces. Serum bilirubin is determined by (1) diazo transfer reaction, currently, the gold-standard; (2) high-performance liquid chromatography (HPLC); (3) oxidative, enzymatic, and chemical methods; (4) direct spectrophotometry; and ...
1. SUMMARY OF TEST PRINCIPLE AND CLINICAL RELEVANCE. Bilirubin is an organic compound formed by the reticuloendothelial system during normal and abnormal destruction of red blood cells. Bilirubin measurements are performed in the diagnosis of liver diseases, in the detection of hemolytic anemia, and to evaluate degrees of jaundice.
12 wrz 2022 · Bilirubin is an important metabolite of heme (ferroprotoporphyrin IX), a coordination complex coordinating iron in various proteins. It is a potentially toxic substance. However, the body has developed mechanisms for its safe detoxification and disposition.
These guidelines deal specifically with the management of abnormal liver blood tests in children and adults in both primary and secondary care under the following subheadings: (1) What constitutes an abnormal liver blood test? (2) What constitutes a standard liver blood test panel? (3) When should liver blood tests be checked?
1 lut 2020 · During the last decades, a lot of attention has been paid to for the improvement of diverse biosensors to measure bilirubin. Serum bilirubin is a vital index for determining to distinct a range of liver diseases. A variety of biosensors geared toward the precise quantity of bilirubin as given below:
1. SUMMARY OF TEST PRINCIPLE AND CLINICAL RELEVANCE The LX20 uses a timed-endpoint Diazo method to measure the concentration of total bilirubin in serum or plasma. In the reaction, bilirubin reacts with diazo reagent in the presence of caffeine, benzoate, and acetate as accelerators to form azobilirubin.
Normal serum bilirubin concentration is usually no greater than 1.5 mg/dl and is composed primarily of the unconjugated form. Jaundice due primarily to hemolysis or a bilirubin conjugation disorder results in a serum bilirubin whose unconjugated component is at least 85% of the total.
