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1. www.nature.com › articles › s41392/021/00868-xEmerging new therapeutic antibody derivatives for cancer...

   www.nature.com › articles › s41392/021/00868-x

   7 lut 2022 · Monoclonal antibodies constitute a promising class of targeted anticancer agents that enhance natural immune system functions to suppress cancer cell activity and eliminate cancer cells.

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2. www.nature.com › articles › s41392/021/00572-wSmall molecules in targeted cancer therapy: advances, challenges,...

   www.nature.com › articles › s41392/021/00572-w

   31 maj 2021 · Over the past two decades, there has been a tremendous shift in cancer treatment, from broad-spectrum cytotoxic drugs to targeted drugs. 1 Compared with traditional chemotherapy drugs, targeted...

3. molecular-cancer.biomedcentral.com › articles › 10New-generation advanced PROTACs as potential therapeutic agents...

   molecular-cancer.biomedcentral.com › articles › 10

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   21 maj 2024 · The use of folate as a targeting moiety allows for selective delivery of potent anticancer agents directly to tumor cells, enhancing their efficacy and reducing systemic toxicity. Clinical evaluation of these novel prodrugs is currently underway, offering hope for improved treatment options for patients with different types of cancers.

4. pubs.acs.org › doi › 10Multiaction Pt(IV) Prodrugs Releasing Cisplatin and Dasatinib Are...

   pubs.acs.org › doi › 10

   31 maj 2024 · Herein, we describe the general design, synthesis, characterization, and biological activity of new multitargeting Pt (IV) prodrugs that combine antitumor cisplatin and dasatinib, a potent inhibitor of Src kinase.

5. pubs.acs.org › doi › 10Multifunctional Iridium(III)–Platinum(IV) Conjugates as Potent...

   pubs.acs.org › doi › 10

   30 cze 2023 · In this article, we report IriPlatins 1–3, a new class of heterobimetallic Ir (III)-Pt (IV) conjugates as multifunctional potent anticancer theranostic agents. In the designed construction, the octahedral Pt (IV) prodrug is tethered to the cancer cell targeting biotin ligand through one of the axial sites and the other axial site of Pt (IV ...

6. www.nature.com › articles › s41591/019/0668-zA selective BCL-XL PROTAC degrader achieves safe and potent...

   www.nature.com › articles › s41591/019/0668-z

   2 gru 2019 · Metrics. Abstract. B-cell lymphoma extra large (BCL-X L) is a well-validated cancer target. However, the on-target and dose-limiting thrombocytopenia limits the use of BCL-X L inhibitors, such as...

7. onlinelibrary.wiley.com › doi › 10Dihydropyrimidinones as potent anticancer agents: Insight into...

   onlinelibrary.wiley.com › doi › 10

   21 mar 2023 · This study is a short review of their synthesis, mechanism of action, and structure–activity relationships (SARs) that are answerable for the anticancer activity of DHPMs and have been thoroughly researched and assessed.