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Based on theories regarding the underlying causes of PMDD, two main treatment options have been developed: (1) targeting the hypothalamus-pituitary-ovary axis by abolishing fluctuations in gonadal hormone levels (e.g. GnRH analogues, oestradiol, combined oral contraceptives (COCs)) and (2)
The aim of this guideline is to provide guidance for the evaluation of medicinal products in the treatment of PMDD. The present document should be conceived as general guidance, and should be read in conjunction with other applicable EU and ICH guidelines (see Section 3). 51 1. Introduction (background) 52. 53. 54. 55. 56. 57. 58. 59. 60. 61. 62.
PMDD is a cyclical mood disorder affecting a subset of menstruating women with a disease burden comparable to other depressive disorders. A significant body of evidence supports the use of SSRIs dosed either continuously or during the luteal phase as an effective first-line treatment for PMDD.
To treat the emotional symptoms of PMDD (e.g., depression, tearfulness, mood swings, anxiety, anger, irritability, fatigue, difficulty concentrating), the majority of experts recommend antidepressant medications.
30 cze 2021 · Once a diagnosis of PMDD is established, first-line treatments include SSRIs, oral contraceptives, and cognitive-behavioral treatment. PMDD treatment with SSRIs is unique from other affective disorders, as intermittent dosing and use of lower dosages are possible.
PMDD treatment options include intermittent or continuous administration of SSRIs, oral contraceptives, cognitive-behavioral treatment, GnRH medications, or hysterectomy-BSO; treatment challenges include appropriate use of intermittent SSRI dosing, nonresponse to SSRIs, managing medications in the context of comorbidities, and managing treatment...
Timing of symptoms. A) In the majority of menstrual cycles, at least 5 symptoms must be present in the final week before the onset of menses, start to improve within a few days after the onset of menses, and become minimal or absent in the week post menses.
