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Pharmacokinetics (PK) describes the time course of drug concentration following dosing [1, 2]. It is broadly characterized by the transfer of drug into, within, and out of the body as: 1. Input—drug movement from the site of administration to the systemic circulation 2. Disposition—drug distribution and elimination from the systemic circulation
Basic Concepts in Pharmacokinetics. Leon Aarons Manchester Pharmacy School University of Manchester. Objectives. Define pharmacokinetics. Describe absorption. Describe distribution. Describe elimination. Why do we study PK?
17 wrz 2013 · Pharmacokinetics (PK) is the study of the time course of the absorption, distribution, metabolism and excretion (ADME) of a drug, compound or New Chemical Entity (NCE) after its administration to...
Pharmacokinetics (PK) describes how the concentration of a dosed drug and its metabolites in body fluids and tissues changes with time. PK models the concentration-time profile using key parameters, such as volume of distribution (Vd), area under the curve
Pharmacokinetics. The quantitative study and characterization of the time course of drug absorption, distribution, metabolism, and excretion. Pharmacokinetic data are mathematical representations (simplifications) of complex physiological processes.
Clinical pharmacokinetics is the application of pharmacokinetic principles to the safe and effective therapeutic management of drugs in an individual patient. Primary goals of clinical pharmacokinetics include enhancing efficacy and decreasing toxicity of a patient’s drug therapy.
The dissociation constant (K) defines the ratio of the concentrations of the dissociated ions and the undissociated acid. Items in square brackets means concentration. This is considered to be an “equilibrium” constant since the compounds are in equilibrium in the solution with one another.
