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PDF. Abstract. Quantitative 18 F-FDG PET is increasingly being recognized as an important tool for diagnosis, determination of prognosis, and response monitoring in oncology. However, PET quantification with, for example, standardized uptake values (SUVs) is affected by many technical and physiologic factors.
range of 55–75 min according to the EANM guidelines 2015 [2 ]. Also the dependency of SUV on acquisition frame times, reconstruction parameters, physical and physiolog-ical factors, and scanner calibrations limits its potential in providing an objective assessment of whole-body PET images across baseline and follow-up studies for robust
Coleman et al. (31) dis-cussed various aspects and technical issues regarding the use of integrated imaging systems, that is, PET/CT. In the present review, the focus is on recommendations and standards given specifically for quantitative 18F-FDG PET oncology studies.
Quantitative measurements such as SUV for interpreting FDG PET scans are limited because of the considerable overlap between SUV measurements in malignant and benign lesions. Most clinical PET interpretations are based on visual assessment of the FDG ac-cumulation as well as the pattern of disease. PET scans after completion of therapy gener-
1 maj 2019 · Introduction: The purpose of this educational exhibit is to shed light on clinical interpretation of the measured SUV in 68Ga-DOTA-TATE PET/CT imaging.
guidelines for comparing FDG PET response results in multi - center trials and for declaring categorical treatment responses based on threshold changes in SUVs after treatment, of which there are four categories: complete metabolic response, partial metabolic response, stable metabolic disease, and progressive metabolic disease.
Having knowledge of the physiological uptake of 18F-FDG and normal organ SUVs is required for the correct interpretation of whole-body 18F-FDG-PET-CT studies. KEY WORDS: CANCER; INFLAMMATION; POSITRON EMISSION TOMOGRAPHY (PET); COMPUTED TOMOGRAPHY (CT); FLUORODEOXYGLUCOSE (FDG); NORMAL ORGANS.
