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1 sty 2009 · The ability of a single 2-mg/kg dose of PGG-Glucan to mobilize GM-CFC into the peripheral circulation of mice is illustrated in Figure 1. Peak mobilization occurred within 30 min of PGG-Glucan administration, at which time approximately a fourfold increase in GM-CFC numbers was observed.
peripheral blood progenitor cells (PBPC). PGG-Glucan (0.5 mg/kg to 16 mg/kg) was administered intravenously to C3H/HeN male mice and blood collected at times rang-ing from 30 min to seven days after injection. Based on granulocyte-macrophage colony-forming cell (GM-CFC) levels, peak mobilization occurred 30 min after a 2 mg/kg PGG-Glucan dose.
1 lut 1999 · PGG-Glucan was incubated with 20 fold molar excess of NaIO 4 for 72 h in the dark, followed by addition of 10–20 fold molar excess of glycerol or ethylene glycol to quench the oxidation reaction. The PGG-Glucan was dialyzed against water, and then reductively labeled with 100 mCi of NaB 3 H 4 (New England Nuclear, Boston, MA). Low molecular ...
25 paź 2005 · A phase II multicenter, double-blind, randomized, placebo-controlled study of three dosages of an immunomodulator (PGG-glucan) in high-risk surgical patients.
27 maj 2024 · Distribution of selected studies according to formulation, type of study, type and dose/concentration of the glucan, route of administration, treatment schedule, immunological activity, and references.
13 mar 2008 · PGG β-glucan-mediated hematopoietic progenitor cell (HPC) mobilization is dependent on MMP-9. (A): FVB WT and MMP-9 KO mice were treated with a single dose of PGG β-glucan (9.6 mg/kg), GCSF, or PGG β-glucan plus GCSF, and PBLs were assayed 24 hours later for CFU.
29 mar 2020 · SGs like PGG glucan, a β-1,3/1,6-glucan triple helix molecule of pharmaceutical grade, or smaller fragments of soluble β-glucan released by macrophages after WGP internalization are recognized as “free floating or unattached” particles.
