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An international multicenter, randomized, double-blind, placebo-controlled study showed a dose-dependent response of PGG-glucan against postoperative infections. β-Glucans are suggested to play an important role in the development of respiratory and organic dust-related diseases.
Patients in treatment groups were administered PGG glucan at a dose of 0.5 mg/kg or 1.0 mg/kg preoperatively and three times postoperatively. Results showed that there was no difference in severe infections and mortality between treatment and placebo groups.
1 sty 2009 · The ability of a single 2-mg/kg dose of PGG-Glucan to mobilize GM-CFC into the peripheral circulation of mice is illustrated in Figure 1. Peak mobilization occurred within 30 min of PGG-Glucan administration, at which time approximately a fourfold increase in GM-CFC numbers was observed.
27 maj 2024 · Distribution of selected studies according to formulation, type of study, type and dose/concentration of the glucan, route of administration, treatment schedule, immunological activity, and references.
29 mar 2020 · The Department of Pediatrics, ChangPing Women and Children Health Care Hospital in China reported that Wellmune supplementation (35 mg day −1 for 12 weeks) kept children healthier during the cold and flu season by significantly decreasing the incidence and duration of the common cold by 66% compared to placebo.
Patients and methods: The study had a 2-stage Simon optimal design with 80% power to detect a target objective response rate (ORR) of ≥10% at a 10% significance level. Patients received weekly Imprime PGG (4 mg/kg) and cetuximab (loading dose, 400 mg/m (2), then 250 mg/m (2)) intravenously.
5 mar 2020 · PGG-Glucan, a soluble β-(1, 3)-glucan, enhances the oxidative burst response, microbicidal activity, and activates an NF-κB-like factor in human PMN: evidence for a glycosphingolipid β-(1, 3)-glucan receptor.
